Yes, the Huion KD100/K20 can work with tablets from other brands. You can use the default functions of KD100/K20 without a driver. If you want to customize the functions of the dial controller and press keys, please download the driver from Huion Official Website.
For Windows OS
If you are using Huion tablets(8192 Pressure Levels), please download the driver① compatible with HUION drawing tablet or monitor(V15 driver only)
If you are using Huion tablets(2048 Pressure Levels) or tablets from other brands, please download the driver② compatible with OTHER drawing tablet or monitor.
For Mac OS
If you are using tablets from other brands, you can download any version of the Mac OS driver.