Conflict between Blender and Huion Windows driver

There is an issue where if Blender crashes, Blender is unable to reopen until you either exit TabletDriver.exe (e.g. in taskbar or Task Manager), temporarily rename System32/wintab32.dll or restart the computer.

https://www.reddit.com/r/blenderhelp/comments/ttgeji/comment/lg2cqk8/

It occurs anywhere from the latest Blender 4.4, to apparently as early as Blender 2.3 as one commenter who owns a Huion tablet said. Another user said it's been an issue for over 4 years now. It's only occurring on Huion tablets, not with any of your competitors. I personally use BForArtists 3.6.2 mostly (user-friendly fork of Blender) and it happens there too, where if it crashes, I often have to exit TabletDriver.exe to be able to reopen Blender.

Unfortunately I don't know how to simulate/force a crash of Blender, but that's what you have to do to reproduce this problem on Windows.

Maybe the easiest way is to crash it is to set render settings higher than the PC can handle using all RAM and forcibly ending the Blender process in Task Manager.

Uninstalling and reinstalling Blender or removing all Blender-related folders in %AppData% does not fix it.

Hopefully your developers can figure out a fix in the future.